When Dr Emma Sweeney stumbles across the victim of a hit and run outside Galway University late one evening, she calls her partner, Detective Cormac Reilly, bringing him first to the scene of a murder that would otherwise never have been assigned to him. A security card in the dead woman's pocket identifies her as Carline Darcy, a gifted student and heir apparent to Irish pharmaceutical giant Darcy Therapeutics. The multi-billion-dollar company, founded by her grandfather, has a finger in every pie, from sponsoring university research facilities to funding political parties to philanthropy - it has funded Emma's own ground-breaking research. The enquiry into Carline's death promises to be high profile and high pressure.

As Cormac investigates, evidence mounts that the death is linked to a Darcy laboratory and, increasingly, to Emma herself. Cormac is sure she couldn't be involved, but as his running of the case comes under scrutiny from the department and his colleagues, he is forced to question his own objectivity. Could his loyalty to Emma have led him to overlook evidence? Has it made him a liability?

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